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Nana, the matriarch of the Cross family. She is Cross's grandmother that took him in when he was 10, since both his parents had died. She is currently entering her 90s, having nearly died in I, Alex Cross and adopting a young girl named Ava in Kill Alex Cross. She is described as a very "old woman", but tough for her age. She is also described by Alex as "stubborn". She usually argues with Alex over several things thus Alex dumbs her as "old woman" and "stubborn". She approves of Alex's new wife, Bree Stone, and considers her to be a daughter to her. Nana was once married to Alex's gandfather, who she was deeply in love with. Once he died, Nana never married again or dated, as it was mentioned in Four Blind Mice. She is also known for always having the last word against 

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